Development of efficient synthetic methods of heterocyclic compounds

Resource-saving technologies are required in the modern society and thus the development of novel and effective procedures for syntheses of useful organic molecules is a crucial issue. From these viewpoints, considering "the effective utilization of carbon resources" and "reduction of chemical wastes", we have developed synthetic methods of heterocycle compounds, which are prevalent in a wide variety of useful compounds (such as medicines, agrichemicals, functional materials and so on), based on catalytic consecutive reactions and multi-component reactions. Since the catalytic system for the catalytic consecutive reactions and multi-component reactions activates plural reactions in one flask, these reactions provides us with not only "simpleness and easiness of operation" but also "improvement of the atom effectiveness" and "reduction of chemical wastes". Recently, we have mainly researched methods with iodine reagents because Japan is abundant in iodine. The following examples are some of our synthetic methods.
1) Syntheses of oxazoles and imidazoles based on [2+2+1]annulations of alkynes, nitriles and heteroatoms mediated by hypervalent iodine reagent as "a activating agent" and "a heteroatom donor"
2) Syntheses of oxazoles and furans concomitantly with incorporation of oxygen functional groups based on the oxidative cycloisomerization of alkynes mediated by hypervalent iodine reagent as "an activating agent" and "a heteroatom donor"
3) Syntheses of dihydroquinolinones and iminoquinolines based on the hetero-enyne metathesis reaction
4) Syntheses of indoles and pyrroles based on the amino-Claisen rearrangement-type reaction